CNS Science is a methodological unit to support the draft, conduct and analysis of clinical research projects’ results, integrated in the Senior Neurological Campus (CNS). With competences in clinical research methodology, neuroscience, rehabilitation, project coordination, statistical data management and analysis and statistical study monitoring, this unit’s team is composed by health professionals and researchers with experience in clinical research and Neurosciences.

CNS Science emerges as a unit focused on the collaboration and integration of different knowledge areas (Medicine, Neuroscience, Data Management and Biostatistics) with the ultimate goal of improving healthcare for patients.

This unit is part of CNS, sharing the same multidisciplinary concept and reconciling a quality clinical activity which leads to research projects and training of health professionals, with particular focus, but not exclusively, in the neurological field diseases, namely Parkinson's Disease, other Movement Diseases and Alzheimer's.

Alzheimer: Aspect Clinical Trial [ON GOING]

Clinical Trials
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Migraine: Embrace 2019 Clinical Trial [ON GOING]

Clinical Trials
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A distinct neuromelanin magnetic resonance imaging pattern in parkinsonian multiple system atrophy

Scientific articles
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Satisfaction of Patients with Nonvitamin K Anticoagulants Compared to Vitamin K Antagonists: a Systematic Review and Meta-analysis

Scientific articles
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Patient-centred management of Parkinson's disease

Scientific articles
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The Role of Architecture and Design in the Management of Parkinson's Disease: A Systematic Review

Scientific articles
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Are Happiness and Well-being the Same Outcome?

Scientific articles
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Correction to: Patient perspectives on the therapeutic profile of botulinum neurotoxin type A in cervical dystonia

Scientific articles
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N-Terminal Pro-B-Type Natriuretic Peptide Levels in Parkinson's Disease

Scientific articles
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Effect of oxygen supply on mortality in acute ST-elevation myocardial infarction: systematic review and meta-analysis

Scientific articles
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Aspirin for Primary Cardiovascular Prevention in Patients with Family History of Cardiovascular Disease: Meta-analysis

Scientific articles
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Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms

Scientific articles
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Patient perspectives on the therapeutic profile of botulinum neurotoxin type A in cervical dystonia

Scientific articles
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A Standardized MR Imaging Protocol for Parkinsonism

Scientific articles
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Challenges and Perspectives in the Management of Late-Stage Parkinson's Disease

Scientific articles
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Cross-cultural adaptation and validation of the Swallowing Disturbance Questionnaire and the Sialorrhea Clinical Scale in Portuguese patients with Parkinson's disease

Scientific articles
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Recommendations for the Organization of Multidisciplinary Clinical Care Teams in Parkinson's Disease

Scientific articles
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Gait Kinematic Parameters in Parkinson's Disease: A Systematic Review

Scientific articles
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Speech intelligibility of Parkinson's disease patients evaluated by different groups of healthcare professionals and naïve listeners

Scientific articles
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Moving towards home-based community-centred integrated care in Parkinson's disease

Scientific articles
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The impact of SSRIs on mortality and cardiovascular events in patients with coronary artery disease and depression: systematic review and meta-analysis

Scientific articles
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Strategies to minimize placebo effects in research investigations

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Guidelines on exercise testing and prescription for patients at different stages of Parkinson's disease

Scientific articles
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Lack of Accredited Clinical Training in Movement Disorders in Europe, Egypt, and Tunisia

Scientific articles
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Neuromelanin Magnetic Resonance Imaging of the Substantia Nigra in Huntington's Disease

Scientific articles
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Outcome Measures for Evaluating the Effect of a Multidisciplinary Intervention on Axial Symptoms of Parkinson's Disease

Scientific articles
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Once- versus Twice-Daily Aspirin in Patients at High Risk of Thrombotic Events: Systematic Review and Meta-Analysis

Scientific articles
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Alzheimer's disease: Embark Clinical Trial [ON GOING]

Clinical Trials
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Pneumococcal vaccination in adults at very high risk or with established cardiovascular disease: systematic review and meta-analysis

Scientific articles
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Cardiovascular Adverse Events Reported in Placebo Arm of Randomized Controlled Trials in Parkinson's Disease

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Treating Patients Like Athletes: Sports Science Applied to Parkinson's Disease

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Anterior Limb of Internal Capsule and Bed Nucleus of Stria Terminalis Stimulation for Gilles de la Tourette Syndrome with Obsessive-Compulsive Disorder in Adolescence: A Case of Success

Scientific articles
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Reply to the letter 'We never speak about sudden unexpected death in Parkinson's disease'

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Contingent negative variation: a biomarker of abnormal attention in functional movement disorders

Scientific articles
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Inhaled levodopa for intermittent treatment of OFF episodes in patients with Parkinson's disease

Artigos Científicos
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Motor, cognitive and mobility deficits in 1000 geriatric patients: protocol of a quantitative observational study before and after routine clinical geriatric treatment - the ComOn-study

Scientific articles
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Parkinson's Disease and Fabry Disease: Clinical, Biochemical and Neuroimaging Analysis of Three Pedigrees

Scientific articles
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PROCare4Life [ON GOING]

Research Projects
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Parkinson Disease Tracker Kinetikos

Research Projects
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Tapentadol Prevents Motor Impairments in a Mouse Model of Dyskinesia

Scientific articles
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The "long and winding road" of the disease-modifying effects of levodopa has not ended yet

Scientific articles
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Parkinson's disease: BouNDless Clinical Trial [ON GOING]

Ensaios Clínicos
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Swimming is compromised in Parkinson's disease patients

Scientific articles
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Reply to letter: Does Parkinson's disease increase the risk of cardiovascular events? A systematic review and meta-analysis

Scientific articles
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Levodopa response in later stages of Parkinson's disease: A case-control study

Scientific articles
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Are genetic and idiopathic forms of Parkinson's disease the same disease?

Scientific articles
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Risk of Developing Parkinson Disease in Bipolar Disorder: A Systematic Review and Meta-analysis

Artigos Científicos
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Should the Energy Contribution of Commercial Thickeners Be Considered in the Nutrition Plan of Patients With Dysphagia?

Scientific articles
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Does Parkinson's disease increase the risk of cardiovascular events? A systematic review and meta‐analysis

Scientific articles
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Orthostatic Hypotension: Theravance 0169 Clinical Trial [ON GOING]

Clinical Trials
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Headaches: Amgen2017 Clinical Trial [ON GOING]

Clinical Trials
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Cardiovascular events reported in randomized controlled trials in restless legs syndrome

Scientific articles
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Multiple sclerosis: O’HAND Clinical Trial [ON GOING]

Clinical Trials
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Adjunctive Therapies in Parkinson's Disease: How to Choose the Best Treatment Strategy Approach

Scientific articles
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Opicapone for the treatment of Parkinson's disease: A review of a new licensed medicine

Scientific articles
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Risk of drowning in people with Parkinson's disease

Scientific articles
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The European Physiotherapy Guideline for Parkinson's Disease: Implications for Neurologists

Scientific articles
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Physician perception versus true efficacy of tetrabenazine for Huntington's disease

Scientific articles
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Zebrafish as an Animal Model for Drug Discovery in Parkinson's Disease and Other Movement Disorders: A Systematic Review

Scientific articles
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Adverse events with botulinum toxin treatment in cervical dystonia: How much should we blame placebo?

Scientific articles
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Effectiveness of opicapone and switching from entacapone in fluctuating Parkinson disease

Scientific articles
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What is Functional Mobility Applied to Parkinson's Disease?

Scientific articles
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Neuromelanin magnetic resonance imaging of the substantia nigra in first episode psychosis patients consumers of illicit substances

Scientific articles
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Why Palliative Care Applies to Parkinson's Disease

Scientific articles
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Feasibility of using risk prompts to prevent falls, dehydration and pulmonary aspiration in nursing homes: a clinical study protocol

Scientific articles
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The launch of opicapone for Parkinson's disease: negatives versus positives

Scientific articles
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A Perspective on Wearable Sensor Measurements and Data Science for Parkinson's Disease

Scientific articles
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Comments on: 'Pyridostigmine bromide versus fludrocortisone in the treatment of orthostatic hypotension in Parkinson's disease - a randomized controlled trial'

Scientific articles
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Overall Survival and Causes of Death in Neurodegeneration-An Overlooked and Underreported Theme

Scientific articles
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Neuromelanin magnetic resonance imaging of the substantia nigra in LRRK2-related Parkinson's disease

Scientific articles
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Substantia Nigra Neuromelanin as an Imaging Biomarker of Disease Progression in Parkinson's Disease

Scientific articles
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Fifteen Years of Clinical Trials in Huntington's Disease: A Very Low Clinical Drug Development Success Rate

Scientific articles
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Palliative Care for Patients and Families With Parkinson's Disease

Scientific articles
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Prevalence of Parkinson's disease: a population-based study in Portugal

Scientific articles
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Opicapone for the treatment of Parkinson's disease

Scientific articles
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Dysarthria in individuals with Parkinson's disease: a protocol for a binational, cross-sectional, case-controlled study in French and European Portuguese (FraLusoPark)

Scientific articles
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Alzheimer Disease: Clinical Trials

Clinical Trials
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Pimavanserin for the treatment of Parkinson's disease psychosis

Scientific articles
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Clinical pharmacology review of opicapone for the treatment of Parkinson's disease

Scientific articles
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Erratum to: A systematic review of the characteristics and validity of monitoring technologies to assess Parkinson's disease

Scientific articles
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New methods for the assessment of Parkinson's disease (2005 to 2015): A systematic review

Scientific articles
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Association Between Body Mass Index and Parkinson Disease

Scientific articles
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Spinal Cord Lesion by Minor Trauma as an Early Sign of Multiple System Atrophy

Scientific articles
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A systematic review of the characteristics and validity of monitoring technologies to assess Parkinson's disease

Scientific articles
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Magnetic resonance correlation of iron content with neuromelanin in the substantia nigra of early-stage Parkinson's disease

Scientific articles
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Parkinson Disease: Clinical Trial MOVES-PD

Clinical Trials
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Cognitive Impairment in Fall-Related Studies in Parkinson's Disease

Scientific articles
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Quantitative home-based assessment of Parkinson's symptoms: the SENSE-PARK feasibility and usability study

Scientific articles
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Substantia nigra neuromelanin-MR imaging differentiates essential tremor from Parkinson's disease

Scientific articles
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Participatory design in Parkinson's research with focus on the symptomatic domains to be measured

Scientific articles
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Alzheimer Disease: Clinical Trial 221AD301

Clinical Trials
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Multiple Sclerosis: Clinical Trial Receptos

Clinical Trials
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Migraine: Clinical Trial AMG334

Clinical Trials
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